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Facilitated α-synuclein oligomer sharing among glial cells by a centrally acting connexin inhibitor attenuates a rapidly progressive multiple system atrophy-cerebellar type model by reducing the neuronal α-synuclein burden

中枢作用性コネキシン阻害剤によるグリア細胞間のα-シヌクレインオリゴマー共有の促進は、神経細胞のα-シヌクレインの負担を軽減することで、急速進行性多系統萎縮症-小脳型モデルを軽減する

Harada M, Masaki K, Tanaka T, Sekiya H, Matsuse D, Yamaguchi H, Nishimura Y, Takase EO, Tanaka E, Kira YI, Fujishima K, Matsuo E, Yamasaki R, Dickson DW, Suzumura A, Taniwaki T, Hoshino T, Isobe N, Takeuchi H, Kira JI.

Acta Neuropathol Commun. 2025 Sep 24;13(1):197. doi: 10.1186/s40478-025-02116-7.

2025

PMID

40993788

https://doi.org/10.1186/s40478-025-02116-7

PSP

Japan

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Facilitated α-synuclein oligomer sharing among glial cells by a centrally acting connexin inhibitor attenuates a rapidly progressive multiple system atrophy-cerebellar type model by reducing the neuronal α-synuclein burden
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